Carmine Cardillo, M.D., is a professor of Internal Medicne and Chief of the Vascular Physiology Laboratory at Catholic University Medical School in Rome, Italy. He has received his M.D. degree and his fellowship in Internal Medicine from the Catholic University and he has also served for almost 4 years as a Visiting Scientist at the Cardiology Branch of NHLBI at the National Institutes of Health in Bethesda, MD, USA. In addition to practicing and teaching, Dr. Cardillo has been involved for decades in clinical research on the mechanisms of vascular dysfunction in patients with cardiovascular risk factors. In particular, he has extensively investigated the changes in the vascular homeostatic mechanisms, including the nitric oxide pathway and the endothelin system, occurring in obese patients according to their different metabolic phenotypes. In addition, he has studied the determinants of dysregulated vasoactive properties of insulin in insulin resistant states and the vasoactive effects of various adipokines, such as leptin and apelin, and gut hormones, such as ghrelin and obestatin, in healthy subjects and obese patients. His studies have been published in leading journals of cardiovascular medicine and metabolism. Dr. Cardillo has been recipient of a number of competitive grants and serves as a frequent reviewer for major journals in the field of his scientific interest.