Pasquale Patrizio

Dr. Pasquale Patrizio is a board-certified specialist in Obstetrics & Gynecology, Reproductive Endocrinology and Infertility, Andrology and has a Master in Bioethics. He is Professor of Obstetrics/Gynecology, Director of the Yale University Fertility Center & Fertility Preservation program, and Teacher of medical bioethics at the Yale Center for Bioethics. He received his MD (summa cum laude) from the University of Napoli in Italy and completed two residencies: one in OB/GYN in Napoli and one in Andrology at the University of Pisa. After moving to US, completed a residency in Obstetrics and Gynecology and a fellowship in Reproductive Endocrinology and Infertility at the UC- Irvine. In August 2003 Dr Patrizio completed a master in Bioethics (MBE) at the University of Pennsylvania and in the same year became also certified as High Complexity Laboratory Director (HCLD). Some of his research and clinical innovation accomplishments include: a) Co-pioneering (with Sherman Silber) the technique of microsurgical epididymal sperm aspiration for men with congenital absence of the vas deferens; b) Discovery that the etiology of congenital absence of the vas deferens is a mild form of cystic fibrosis (awarded first prize paper from the Pacific Coast Fertility Society and the European Society of Human Reproduction meeting); c) Discovery that some cases of male infertility are due to deletions on the Y-chromosome; d) Isolation and freezing of human spermatogonial cells (this work received two prizes from the American Society of Reproductive Medicine); e) Pioneered the technique of whole ovary cryopreservation via multi thermal gradient for fertility preservation; f) Co-authored the first guidelines for fertility preservation for cancer patients on behalf of ASCO; g) Published the first complete set of gene expression profiles in human oocytes at different stages of maturity, whether matured in vitro or in vivo; h) Published and patented the differential gene expression profiles of cumulus cells associated with euploid or aneuploid oocytes (this work was awarded ESHRE first prize for basic research); i) Deciphered molecular mechanisms responsible for oocyte aging. His main current research interests include: Improving the efficiency of ART, reducing multiple pregnancy, fertility preservation strategies, ovarian aging, simplifying IVF laboratory by automation of egg freezing and revolutionize the storage of gametes (sperm and eggs), embryos, reproductive tissue and stem cells by lyophilization. He is a fellow of the International Academy of Human Reproduction, a restricted (36 members only), international elite group of experts and teachers of Reproductive medicine. In addition, he served as president of International Society Fertility Preservation (ISFP, 2015-2017), Chair of the Regenerative Medicine and Stem Cell Biology special interest group and is the newly elected Chair of the Fertility Preservation special interest group (2019-2020). He has authored 6 books, 525 scientific papers (76 book chapters, 183 peer-reviewed publications and 260 abstracts).