I have extensive training and experience in the design, analysis, and interpretation of both descriptive and analytic epidemiologic studies. My gastric cancer research agenda focuses on defining 1) Helicobacter pylori virulence factors that contribute to cancer risk, 2) non-invasive markers for advanced premalignant and malignant gastric lesions, and 3) reasons for population disparities in cancer incidence. My analyses of cancer registration data indicate that the epidemiology of gastric cancer in the United States is changing. Current trends foreshadow expected reversals in both falling incidence and male predominance among non-Hispanic whites. Dysbiosis of the gastric microbiome associated with modern living conditions may be increasing risk of autoimmune gastritis and consequently noncardia cancer.