Giuseppe Penno

RESEARCH EXPERIENCES ! Epidemiology of micro- and macrovascular complications in type 1 and type 2 DM (Italian Microalbuminuria Study Group, IMSG; EURODIAB IDDM Complications Study; EURODIAB Prospective Complications Study, EURODIAB PCS; EURODIAB Family Study; Renal Insufficiency and Cardiovascular Events, RIACE Study) ! Diabetes, hypertension, and diabetic complications: international trials with ACE-inhibitors, Angiotensin II receptor antagonists, renin inhibitors, sulodexide (EUCLID Study; IDNT Study; ALTITUDE; Sulodexide Microalbuminuria Trial, Sun-MICRO; Sulodexide Overt Nephropathy Trial, Sun-MACRO) ! Metabolic Syndrome: endothelial dysfunction, impaired glucose tolerance, hypertension ! Microalbuminuria and diabetic nephropathy: methods for screening and diagnosis, changing natural history and biomarkers ! Genes and microvascular/cardiovascular diabetic complications ! Essential hypertension: endothelial dysfunction, microalbuminuria, effects of the anty-hypertensive treatment and of lipid-lowering drugs on the endothelial function ! Atherosclerosis and dyslipidemias ! Prevention of type 2 diabetes, pre-diabetes, and metabolic syndrome ! Cell cultures: human mesangial cells, HUVECs, endothelial progenitor cells (EPCs) ! Endothelial dysfunction and EPCs in diabetes, pre-diabetes, and gestational diabetes ! New glucose-lowering agents and diabetic kidney disease (DERIVE, FLOW, CONFIDENCE) RESEARCH PROJECTS OF INTERNATIONAL RELEVANCE ! Italian Microalbuminuria Study. ! EURODIAB IDDM Complication Study. ! EURODIAB PCS (prospective Complication Study). ! EURODIAB controlled trial of lisinopril in insulin dependent diabetes (EUCLID). ! IDNT: Irbesartan Diabetic Nephropathy Trial. ! Effect of Sulodexide in patients with type 2 diabetes and Microalbuminuria & Effects of Sulodexide in patients with Overt Type 2 Diabetic Nephropathy. 1 ! EU Project DE-PLAN (Prevention using Lifestyle, Physical Activity and Nutritional Intervention). ! ALTITUDE - Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints. ! ePREDICE (Early Prevention of Diabetes Complications in Europe) ! Dapagliflozin DERIVE Study - D1690C00024 - A multicenter, double-blind, placebo-controlled, phase III trial to evaluate the glycaemic efficacy and renal safety of dapagliflozin in patients with type 2 diabertes mellitus with moderate renal impairment (CKD 3A) who heve inadequate glycemic control. ! FLOW - Effect of semaglutide versus placebo on the progression of renal impairment in subjects with type 2 diabetes and chronic kidney disease (CKD). RESEARCH PROJECTS OF NATIONAL RELEVANCE ! GENFIEV (GENetics, pathoPHYsiology and EVolution of type 2 diabetes) study ! RIACE (Renal Insufficiency and Cardiovascular Events) ! Polychemotherapy to induce remission of newly diagnosed type 2 diabetes: a proof-of-concept study of efficacy, cost-efficac and pathophysiologic mechanisms (MIRACLE) MEMBERSHIP OF SCIENTIFIC SOCIETY SID: Società Italiana di Diabetologia EASD: European Association for the Study of Diabetes EDNSG: European Diabetic Nephropathy Study Group REVIEWER FOR Acta Diabetologica; American Journal of Hypertension; BMC Nephrology; BMJ Open; Clinical Chemistry and Laboratory Medicine; Clinical Medicine & Research; Current Medical Research & Opinion; Diabetes and Its Complications; Diabetes/Metabolism Research and Reviews; Diabetes Research and Clinical Practice; Diabetic Medicine; Diabetologia; Endocrine Research; European Journal of Clinical Investigation; International Journal of Endocrinology; Journal of Endocrinological Investigation; Journal of Hypertension; Journal of Internal Medicine; Nephrology Dialysis Transplantation; Nutrition, Metabolism and Cardiovascular Disease; PLOS ONE; Postgraduate Medicine; Vascular Pharmacology PUBLICATIONS More than 280 papers on national/international journals (180 publications recorded by PubMed). Furthermore, listed in PubMed, 81 publications as collaborator of EURODIAB IDDM Complications Study and EURODIAB PCS (EURODIAB Prospective Complications Study); 5 as collaborator of EUCLID Study (EURODIAB Controlled Trial of Lisinopril in IDDM); 21 as collaborator of IDNT Study (Irbesartan Diabetic Nephropathy Trial); 3 as collaborator of GENFIEV Study (GENetics, pathoPHYsiology and EVolution of type 2 diabetes); 2 as collaborator of IMSG (Italian Microalbuminuria Study Group); 1 as collaborator of TOSCA.IT (Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial). More than 500 abstracts or proceedings presented at National and International Meetings.