Giuseppe Paolisso is a Top Italian Scientistis (TIS) http://www.topitalianscientists.org/TIS_HTML/Top_Italian_Scientists_Biomedical_Sciences.htm Current Position • Rector, University of Campania Luigi Vanvitelli • Full Professor of Internal Medicine and Geriatrics, Department of Advanced Medical and Surgical Science, University of Campania “Luigi Vanvitelli” • Director of Division of Internal Medicine and GEARITRIC Disease, University of Campania “Luigi Vanvitelli” Hospital (AOU), Piazza Miraglia, Naples (Italy). Formation. • Degree in Medicine and Surgery, cum laude. • Specialist in Geriatric Medicine cum laude. • Specialist in Diabetes and Metabolic Disease cum laude. • Research Fellow-National Institute of Health-Clinical Diabetes and Nutrition Section Phoenix -AZ, (USA) • Research Fellow- University of Liege (BE). • Research Fellow - Department of Physiology, Catholic University, Brussels (BE). Research Interests. • Study of the molecular and metabolic aspects of aging and longevity including the relationships between aging, glucose metabolism and cardiovascular diseases. • Study of the role of lifestyle in preventing fragility. Definition of the cardiometabolic risk in the elderly patient. • Study of glycemic variability and its relation to the development of diabetic. Cardiovascular complications in adults and the elderly. • Study of the relationship between glycemic variability and cognitive and functional decline. Study of the role of the different genetic polymorphisms in metabolic diseases linked to aging and determinism of longevity. • Study of epigenetic modifications (methylation, miRNA etc, histone modifications).