Florian Kühn

Current Position: Senior Physician / Attending Surgeon, Department of General, Visceral, and Transplant Surgery, LMU Munich Since 01/2021 Head, Colorectal Cancer Center, LMU Munich 01/2020 – 01/2021 Coordinator, Colorectal Cancer Center, LMU Munich Since 02/2020 Assistant Professor of Surgery, LMU Munich Since 09/2017 Department of General, Visceral, and Transplant Surgery Hospital of the Ludwig-Maximilians-University of Munich Campus Großhadern 2015-2017 Postdoctoral Research Fellow (DFG), Hodin Laboratory of Gastrointestinal Epithelial Biology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA Since 07/2015 Board certification as Visceral Surgeon 12/2008-12/2015 Surgical Residency; Department of General, Visceral, Vascular, Thoracic-, and Transplant Surgery, University Hospital of Rostock, Rostock, Germany 11/2008 Approbation and Medical license (MD) Academic & Research Experience Since 01/2020 Research group leader “Gastrointestinal Homeostasis, Inflammation, and Cancer“, LMU Munich SEITE 2 VON 3 Since 01/2020 Research group leader “Colorectal Cancer and Surgery” Since 02/2020 Assistant Professor of Surgery 2015-2017 Postdoctoral Research Fellow, Hodin Laboratory of Gastrointestinal Epithelial Biology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA 2009-2016 Research Group Molecular Oncology and Immunotherapy (M.O.I.), Group leader: Michael Linnebacher, Phd; University of Rostock, Rostock, Germany 2006-2010 Doctoral Thesis; Prof. Dr. Joerg Emmrich, Department of Gastroenterology, University of Rostock Member Medical Societies - German Society for Surgery (DGCH) - German Society for General and Visceral Surgery (DGAV) - German Surgical Research (SCF / DGCH) - Society of Surgery of the Alimentary Tract (SSAT) - American College of Surgeons (ACS) Selected Publications: 1. Liu Y, Cavallaro PM, Kim BM, Liu T, Wang H, Kühn F, Adiliaghdam F, Liu E, Vasan R, Samarbafzadeh E, Farber MZ, Li J, Xu M, Mohad V, Choi M, Hodin RA. A role for intestinal alkaline phosphatase in preventing liver fibrosis. Theranostics 2021; 11(1): 14-26. eCollection 2021. Impact factor: 11,6 2. Lu C, Schardey J, Zhang T, Crispin A, Wirth U, Karcz KW, Bazhin AV, Andrassy J, Werner J, Kühn F. Survival Outcomes and Clinicopathological Features in Inflammatory Bowel Disease-Associated Colorectal Cancer: A Systematic Review and Meta-Analysis. Ann Surg 2021; Online ahead of print. Impact factor: 12,97 3. Kühn F, Adiliaghdam F, Cavallaro PM, Hamarneh SR, Tsurumi A, Hoda RS, Munoz AR, Dhole Y, Ramirez JM, Liu E, Vasan R, Liu Y, Samarbafzadeh E, Nunez RA, Farber MZ, Chopra V, Malo MS, Rahme LG, Hodin RA. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. JCI Insight 2020; 5(6):e134049. Impact factor: 8,3 4. Adiliaghdam F, Cavallaro P, Mohad V, Almpani M, Kühn F, Gharedaghi MH, Najibi M, Rahme LG, Hodin RA. Targeting the gut to prevent sepsis from a cutaneous burn. JCI Insight 2020; 5(19):e137128. Impact factor 8,3 5. Kühn F, Wirth U, Zimmermann J, Beger N, Hasenhütl S, Drefs M, Heiliger C, Burian M, Werner J, Schiergens TS. Endoscopic vacuum therapy for in- and outpatient treatment of colorectal defects. Surg Endosc 2020; Online ahead of print. Impact factor: 4,6 SEITE 3 VON 3 6. Wirth U, Garzetti D, Jochum LM, Spriewald S, Kühn F, Ilmer M, Lee SML, Niess H, Bazhin AV, Andrassy J, Werner J, Stecher B, Schiergens TS. Microbiome Analysis from Paired Mucosal and Fecal Samples of a Colorectal Cancer Biobank. Cancers 2020; 12(12):3702. Impact factor: 6,6 7. Chen C, Neumann J, Kühn F, Lee SML, Drefs M, Andrassy J, Werner J, Bazhin AV, Schiergens TS. Establishment of an Endoscopy-Guided Minimally Invasive Orthotopic Mouse Model of Colorectal Cancer. Cancers 2020; 12(10):3007. Impact factor: 6,6 8. Zhao C, Wang Q, Wang B, Sun Q, He Z, Hong J, Kuehn F, Liu E, Zhang Z. IGF-1 induces the epithelialmesenchymal transition via Stat5 in hepatocellular carcinoma. Oncotarget 2017; 8: 111922-111930. Impact factor: 6,4 9. Kuehn F, Mullins CS, Krohn M, Harnack C, Ramer R, Krämer OH, Klar E, Huehns M, Linnebacher M. Establishment and characterization of HROC69 - a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft. Sci Rep 2016; 6: 24671. Impact factor: 5,6 10. Pérot P, Mullins CS, Naville M, Bressan C, Hühns M, Gock M, Kühn F, Volff JN, Trillet-Lenoir V, Linnebacher M, Mallet F. Expression of young HERV-H loci in the course of colorectal carcinoma and correlation with molecular subtypes. Oncotarget 2015; 24; 6:40095-111. Impact factor: 6,4