Bernardo Bonanni

I am the Director of the Division of Cancer Prevention and Genetics at the European Institute of Oncology (IEO) in Milan, Italy. My clinical interests are mainly focused on the identification and selection of high risk subjects (being patients with a precancerous condition or healthy subjects carrying one or more risk factors including genetic predisposition) and on their management in terms of surveillance and clinical trial participation. I have an established experience on the design, implementation and conduction of various types of trials including: a) phase II studies on surrogate endpoint biomarkers (SEBs); b) large phase III, multi-institutional trials on clinical endpoints (cancer incidence); c) “window of opportunity” studies in patients candidate to surgical treatment for primary breast cancer in order to test the efficacy of new and “old” drugs on breast cancer cell proliferation (measured by ki-67 in baseline biopsy and in the specimen after 3-4 weeks of treatment) and other tissue biomarkers. B. Positions, Scientific Appointments, and Honors Positions and Employment 1985-1986 Resident in the General Surgery Department and Oncological Outpatient Clinic of the Civic Hospital, Carrara (MS) 1986-1987 Military service in the Army Medical Corps 1987-1988 Resident in the OCD Department of the National Cancer Institute, Milan 1989-1990 Resident in the General Surgery Department of the Serbelloni Hospital, Gorgonzola (MI) 1987-1989 Part-time work in the National First-Aid Service and as a General Practitioner 1990-1992 Junior Assistant in the Emergency Department of the Serbelloni Hospital, Gorgonzola (MI) 1993 Observer, Clinical Breast Service of the Memorial Sloan-Kettering Cancer Center, New York, USA 1992-1994 Clinical Researcher, Italian Trial of \"Breast Cancer Chemoprevention with Tamoxifen\" in the Central Operative Unit, Milan and at the Istituto Nazionale Tumori, Milan 1994-1995 Clinical Researcher, Italian Trial of \"Breast Cancer Chemoprevention with Tamoxifen\" in the Central Operative Unit of Milan and Clinical fellow in the Division of Senology of the European lnstitute of Oncology, Milan 1995-2001 Junior Assistant, Chemoprevention Unit, European Institute of Oncology, Milan 2002-2003 Senior Assistant, Division of Chemoprevention, European Institute of Oncology, Milan 2004-2007 Co-director, Division of Chemoprevention, European Institute of Oncology, Milan 2007- Director, Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan.