Barbara Casadei is a British Heart Foundation (BHF) Professor of Cardiovascular Medicine at the University of Oxford and Honorary Consultant Cardiologist at the Oxford University Hospitals NHS Trust where she leads the Cardiovascular Theme of the National Institute for Health Research (NIHR) Biomedical Research Centre and is Steering Committee Member of the BHF Centre for Research Excellence. Professor Casadei graduated in Medicine (cum Laude & Gold Medal) at the University of Pavia, Italy and moved to Oxford in 1989 to undertake her clinical and research training. She was awarded the Joan and Richard Doll Fellowship at Green College in 1991, a DPhil in Cardiovascular Medicine in 1995, and a BHF Senior Research Fellowship in 2001. She is Fellow of the UK Academy of Medical Sciences, holds the highest honour of the British Cardiovascular Society (The Mackenzie Medal) and of the European Society of Cardiology (Gold Medal), and is the Immediate Past President of the ESC. Professor Casadei is member of several Scientific Advisory (e.g., the Fondation Leducq, the Netherlands Heart Institute, and the LIRYC Research Institute) and Editorial Boards (e.g., Cardiovascular Research; Circulation; European Heart Journal; Circulation Research) and has delivered numerous international prize lectures including, The William Harvey Lecture on Basic Science and Silver Medal of the ESC, 2013; The Thomas Lewis Lecture and Silver Medal of the British Cardiovascular Society, 2014; The Carmeliet-Coraboeuf-Weidmann Lecture of the European Heart Rhythm Association, 2015; The Brutsaert Lecture of the European Heart Failure Association, The William H Gaasch Lecture, University of Massachusetts, 2017, The Michael Sole Lecture, University of Toronto, 2019 and the Roman W. DeSanctis Lecture, Harvard Medical School, US, 2021. She provides a clinical service at the John Radcliffe Hospital and leads a bench-to-bedside translational research programme, which spans from bench-based investigation in human tissue and cells to clinical trials.